Plantar fibromatosis:
Plantar fibromatosis involves pain and disability caused by the thickening of the feet's deep connective tissue and patients often have Dupuytren’s disease, Peyronie’s disease and adhesive capsulitis. Current treatments include orthotics and anti-inflammatory drugs in the early stages of the disease, steroid injections and surgery in advanced cases. Currently, 400,000 surgeries are performed per year in this indication, with a prevalence rate of 5-11%.
Adhesive capsulitis:
Adhesive capsulitis involves inflammation and thickening of shoulder capsule due to collagen, limiting the range of motion of the shoulder. Common available treatment options are often painful and can require anesthesia and this condition can last from about one year to over three. Currently, 200,000 surgeries are performed per year in this indication, with a prevalence rate of 2-5%.