Frozen shoulder (Adhesive Capsulitis) is a clinical syndrome of pain and decreased motion in the shoulder joint. It is estimated to affect 2-5% of the general population with a slightly higher incidence in women. It typically occurs between the ages of 40-70. Individuals with insulin dependent diabetes have been reported to have a 36% higher incidence rate and are more likely to have a greater likelihood of bilateral symptoms.

Results of a Phase 2 randomized double blind, placebo controlled, dose response study were discussed in an oral presentation at the annual meeting of the American Academy of Orthopaedic Surgeons (AAOS) in March 2006. Based on Auxilium’s prior review of the data contained in the oral presentation, they elected to exercise their option to develop and commercialize this additional indication for collagenase injection in December 2005.

Frozen shoulder reference

Useful Websites:

http://www.nlm.nih.gov/medlineplus/ency/article/000455.htm